Fluticasone is a steroid. It prevents the release of substances in the body that cause inflammation. Salmeterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Together, Advair is used to prevent asthma attacks. It is used only to prevent asthma attacks, not to treat an attack already in progress. It will not work fast enough to give relief during an attack. Advair is also used in the treatment of chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis
Serious side effects from Advair are not likely to occur. If you experience any of the following serious side effects, stop using Advair and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); chest pain or irregular heartbeats; numbness, tingling, or pain; a rash or unexplained open sores or bruising; or worsening breathing or asthma symptoms. Other, less serious side effects may be more likely to occur. Continue to take Advair and talk to your doctor if you experience dry mouth, nose, or throat after use; yeast (or another) infection in the mouth or throat (white patches); hoarseness or deepening of the voice, cough, or sore throat; nausea, vomiting, or diarrhea; dizziness, headache, tremor, or nervousness.
Avoid known items or activities that may worsen symptoms of asthma or bronchitis. Clean areas where dust or pet fur may aggravate your condition. Avoid exposing yourself to known sources of infection. Stay away from people with chicken pox, measles, or any other type of infection. Your immune system may not be strong enough to fight off an infection while using Advair.
Before using Advair, tell your doctor and pharmacist if you are taking any of the following medications: another oral, nasal, or inhaled steroid; a beta-blocker such as atenolol (Tenormin), metoprolol (Lopressor), propranolol (Inderal), and others; a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate); a tricyclic antidepressant such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), and others; a diuretic (water pill) such as hydrochlorothiazide (HydroDiuril, Esidrix, Oretic, Microzide), chlorothiazide (Diuril), furosemide (Lasix), and others; caffeine (in food or medicines), a diet medicine, or a decongestant such as pseudoephedrine or phenylephrine; a protease inhibitor such as ritonavir (Norvir); or an antifungal medicine such as ketoconazole (Nizoral) or itraconazole (Sporanox). You may not be able to use fluticasone and salmeterol, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
If you take too much:
Seek emergency medical attention if an overdose is suspected. Symptoms of a salmeterol and fluticasone overdose may include angina or chest pain, irregular or rapid heartbeats, seizures, tremor, weakness, headache, nausea, and vomiting.
Take the missed dose as soon as you remember. If it is almost time for the next regularly scheduled dose, skip the missed dose and use the next one as directed. Do not use a double dose of this medication.
Store this medication at room temperature away from moisture and heat. The Diskus inhalation device is not reusable. Throw away the device 1 month after removal from the moisture-protective foil overwrap pouch or after all doses have been used (when the dose indicator reads "0"), whichever comes first. There are 60 doses per Diskus. Do not attempt to take the device apart.